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terça-feira, 21 de agosto de 2012

TB Vaccine Promising as New Way to Fight Type 1 Diabetes


One expert said the finding was important, but many questions remain.
"This study shows that by increasing TNF, they can induce the death of the autoreactive T-cells that destroy the cells that make insulin, and they transiently increase C-peptide levels," said Dr. Spyros Mezitis, an endocrinologist at Lenox Hill Hospital in New York City. "But what happens after 20 weeks? How often would they need to give this vaccine?"
"I'm concerned about increasing the levels of TNF in the body," he added. "They're saying that only the insulin-secreting cells are affected, but what are the long-term effects if it's given repeatedly? What about the growing cells in children, because if it works it would be used in children."
Still, he said, "this is important research that helps us understand the pathophysiology of type 1 diabetes."

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